Locking On and Guarding are techniques in both installments of the No More Heroes video game series which can be performed by holding the Z Button. This allows the player to both lock onto a nearby enemy or select objects, and enable auto-guarding, so long as Travis Touchdown is not being moved by the Control Stick. While playing the game on the Sweet difficulty, auto-guarding can also be enabled by simply not tilting the Control Stick, regardless of whether or not the Z Button is being held. When an enemy is Locked On, a lock-on circle, their remaining health and the amount of hits they've taken are displayed. While Locked On, Touchdown can move about without turning his back on the opponent. In No More Heroes 2: Desperate Struggle, the lock-on circle itself serves as the enemy's health gauge, with damage dealt represented in red and health remaining represented in green.

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